Afirma also offers malignancy classifiers to guide physicians in choosing between surgery and observation. SUMMARY OF THE STUDIES. The results were presented at the 87th Annual Meeting of the American Thyroid Association, Oct. 18–22, in Victoria, British Columbia, Canada. 2021 Jan 1;7(1):70-77. doi: 10.1001/jamaoncol.2020.5935. University of California, Los Angeles. Evaluation of 167 Gene Expression Classifier (GEC) and ThyroSeq v2 Diagnostic Accuracy in the Preoperative Assessment of Indeterminate Thyroid Nodules: Bivariate/HROC Meta-analysis. Negative Results on Thyroid Molecular Testing Decrease Rates of Surgery for Indeterminate Thyroid Nodules. Careers. Livhits MJ, Zhu CY, Kuo EJ, Nguyen DT, Kim J, Tseng CH, Leung AM, Rao J, Levin M, Douek ML, Beckett KR, Cheung DS, Gofnung YA, Smooke-Praw S, Yeh MW. I ran AFIRMA and then another doc did a Quest Diagnostic Panel-- it tested about 7 genes, so not as comprehensive as the Thyroseq. Parallel randomized trial, monthly block randomization of patients with Bethesda III/IV cytology to GEC or ThyroSeq v2. “The Pittsburgh test can determine if you have an 80 to 100% risk of cancer and can offer the patient a total thyroidectomy up front, to avoid two surgeries,” Dr. Ferris says. You've disabled cookies in your web browser. Endocr Pathol. ThyroSeq v2 had higher specificity than Afirma GEC and allowed more patients to avoid surgery. Patients who underwent thyroid biopsy (April 2016 to June 2017). Context: Goldner WS, Angell TE, McAdoo SL, Babiarz J, Sadow PM, Nabhan FA, Nasr C, Kloos RT. ClinicalTrials.gov NCT02681328. This study also compared the performance of ThyroSeq V3 GC with that of another commonly used test for thyroid nodules, the Afirma GSC (Veracyte Inc, South San Francisco, California), as reported elsewhere. ThyroSeq® stratifies these nodules into those that are likely benign and may be observed and those that are likely malignant and require surgical management. Afirma GEC vs. ThyroSeq v.2 in indeterminate thyroid nodules post best practices surgery [ Time Frame: 12 months. Compare the diagnostic performance of Afirma Gene Expression Classifier (GEC) with that of ThyroSeq v2 next-generation sequencing assay. Find a Doctorfor the Afirma test. It uses DNA, mRNA, and miRNA markers for evaluation. If you have, or suspect that you have, a thyroid nodule and would like to find a doctor in your area who performs the Afirma test, simply fill out the information form here. 54. Additional information is available in this. You're a power user moving through this website with super-human speed. 2019 Nov;29(11):1594-1605. doi: 10.1089/thy.2019.0278. The negative predictive value of ThyroSeq v3 was significantly higher for AUS/FLUS (99.5%) than for FN/SFN (95.4%; P < .0294), given malignancy rates of 10% for AUS/FLUS and 30% for FN/SFN. 8600 Rockville Pike alongside or reflexively to Afirma GSC. However, the shared gene panel tested by the prior and current versions of each test encompass the most commonly mutated genes in thyroid cancer (11, 29, 30). This site needs JavaScript to work properly. Some reports have suggested that samples with Hurthle cell predominance have higher false-positive rates on GEC testing, but data are … Molecular testing for indeterminate thyroid nodules: Performance of the Afirma gene expression classifier and ThyroSeq panel. Design: Molecular Variants and Their Risks for Malignancy in Cytologically Indeterminate Thyroid Nodules. Refer to the specific Health Plan's procedure code list for management requirements. Front Endocrinol (Lausanne). It did determine that I had the BRAF mutation in the smaller nodule. Epub 2019 Sep 27. Results: ThyroSeq benign call rate was 71%. Of 1372 thyroid nodules, 176 (13%) had indeterminate cytology and 149 of 157 eligible indeterminate nodules (95%) were included in the study. ThyroSeq had a high NPV of 98%; all missed cancers were ATA low risk. The specificities of GEC and ThyroSeq v2 were 66% and 91%, respectively (P = 0.002); the positive predictive values of GEC and ThyroSeq v2 were 39% and 57%, respectively. Afirma GEC or GSC™ — a gene-expression classifier that identifies biopsies as “benign” or “suspicious,” and; mir-THYtype™ — an mRNA-based classifier test. Zhao H, Jing W, Li W, Zhang Z, Cao J, Zhao L, Sun Y, Wang C, Wang Y, Guo H. J Cancer. The Role of Molecular Diagnostics in the Management of Indeterminate Thyroid Nodules. eCollection 2018. Trial registration: Procedure addressed by this guideline Procedure code ThyroSeq 0026U As you were browsing something about your browser made us think you were a bot. Thyroseq™ Effectiveness of Molecular Testing Techniques for Diagnosis of Indeterminate Thyroid Nodules: A Randomized Clinical Trial. Would you like email updates of new search results? With the use of ThyroSeq V2, 2 patients had false positive results, while 5 had true positive results. Of nodules tested with GEC, 49% were suspicious, 43% were benign, and 9% were insufficient. These 3 papers report the performance of these assays in evaluating Bethesda III and IV indeterminate biopsies. Main outcome measure: Clipboard, Search History, and several other advanced features are temporarily unavailable. ThyroSeq is an innovative test for thyroid nodules and cancer. Thyroseq v3 showed the best overall performance (AUC 0.95; 95% confidence interval: 0.93-0.97), followed by Afirma GSC (AUC 0.90; 0.87-0.92) and Thyroseq v2 (AUC 0.88; 0.85-0.90). You've disabled JavaScript in your web browser. 2020 Oct 21;11(24):7276-7282. doi: 10.7150/jca.46086. No studies have directly compared molecular testing techniques. A comparison of the diagnostic performance between the Afirma genomic sequencing classifier RNA test and the ThyroSeq v3 multigene genomic classifier DNA-RNA test revealed no statistically significant differences in sensitivity and specificity for diagnosis of malignancy in cytologically indeterminate thyroid nodules. Borowczyk M, Szczepanek-Parulska E, Olejarz M, Więckowska B, Verburg FA, Dębicki S, Budny B, Janicka-Jedyńska M, Ziemnicka K, Ruchała M. Endocr Pathol. In recent years, the use of molecular marker testing on thyroid biopsy specimens has helped identify benign indeterminate nodules and avoid surgery. Up to 10-20% of thyroid biopsies are indeterminate, meaning that a diagnosis of cancer vs benign cannot be made on the basis of examining the cells alone. After completing the CAPTCHA below, you will immediately regain access to the site again. Privacy, Help The ThyroSeq test has been in use for …

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