In addition, lymph node metastases were not detected in any noninvasive, encapsulated FVPTCs. The following FVPTCs were included in the study: FVPTC that measured ≥1 cm in greatest dimension with no associated thyroid malignancy except for the presence of 1 or 2 subcentimeter papillary microcarcinomas. When FVPTC is nonencapsulated and infiltrates the surrounding thyroid parenchyma or diffusely involves the thyroid, the diagnosis of carcinoma usually poses no problem.7 For the encapsulated tumor without invasion of surrounding thyroid tissue, the diagnosis of malignancy relies solely on the presence of the nuclear features of PTC (e.g., nuclear clearing, grooves, pseudoinclusions), which often can be borderline. There is no comprehensive, community hospital based longitudinal evaluation of encapsulated follicular variant of papillary thyroid carcinoma. There is continuous debate regarding the optimal classification, prognosis, and treatment of the follicular variant of papillary thyroid carcinoma (FVPTC). It is the most common thyroid cancer in adults. Follicular variant JRC:2666: Papillary carcinoma, encapsulated follicular variant in a 36 y/o male. Prevalence of encapsulated follicular variant of papillary thyroid carcinoma at different time intervals . Their variants include columnar, diffuse sclerosing, follicular variant of papillary, Hürthle cell, and tall cell. Recent studies have described an encapsulated and an infiltrative form of follicular variant of papillary thyroid carcinoma (FVPTC). PTC is the most frequent type of thyroid malignancy (>70% of tumors): It often is multifocal, nonencapsulated, and spreads through the lymph nodes.1 In contrast, FTC is unifocal, encapsulated, and metastasizes directly to distant organs with a very low incidence of lymph node metastases.1 The nuclear features of papillary carcinoma (e.g., nuclear clearing, grooves, pseudoinclusions) characterize a carcinoma that belongs to the PTC family.1 The follicular variant of PTC (FVPTC) is the most common subset of papillary carcinoma and is found in 9% to 22.5% of patients with PTC.2-5 This variant is composed entirely or almost completely of follicles, which are lined by cells that have the nuclear features of papillary carcinoma.6 Thus, FVPTC shares with FTA and FTC the presence of follicles. 2010;23(9):1191-1200.Google Scholar Crossref A clinicopathologic study of 241 cases treated at the University of Florence, Italy, Follicular variant of papillary thyroid carcinoma. The study was approved by the Institutional Review Board of Memorial Sloan-Kettering Cancer Center. In practical terms, a lack of capsular or vascular invasion should denote a benign clinical behavior in encapsulated FVPTC. variant, infiltrative. 1, 2). Mod Pathol. Crossref, Medline, Google Scholar In general, patients with papillary cancer, the most common type of thyroid cancer, have a better prognosis than patients with follicular cancer have. 2010;23(9):1191-120020526288PubMed Google Scholar Crossref prognosis, and treatment of the follicular variant of papillary thyroid carcinoma (FVPTC). The intravascular tumor growth had to be covered by endothelium or attached to the vessel wall. Papillary Carcinomas, Tumors of the thyroid gland. The suggested relationship between the follicular variant of papillary thyroid carcinoma (FVPTC), classic papillary thyroid carcinoma (PTC), and follicular thyroid adenoma/follicular thyroid carcinoma (FTA/FTC) is illustrated based on the histologic, clinical, and molecular data available to date. We studied 77 FVPTCs resected between 2000 and 2002 and characterized the tumors as encapsulated, PE/WC, or infiltrative. METHODS. Sixty-nine patients fulfilled this criteria (Table 3) with a median follow-up of 10.8 years (range, 1.2–21 years). A clinicopathologic study, Papillary thyroid carcinoma: prognostic index for survival including the histological variety, Follicular carcinomas. JRC:18913: Papillary carcinoma of the thyroid (classic type). An unusually high prevalence of ras mutations, Follicular variant of papillary thyroid carcinoma: a comparative study of histopathologic features and cytology results in 141 patients, Follicular variant of papillary thyroid carcinoma: genome-wide appraisal of a controversial entity, PAX8-PPARgamma rearrangement is frequently detected in the follicular variant of papillary thyroid carcinoma, Papillary carcinoma of the thyroid. Encapsulated Thyroid Carcinoma of Follicular Cell Origin. Rivera M, Ricarte-Filho J, Knauf J, et al. A discussion of its several morphologic expressions, with particular emphasis on the follicular variant, Follicular variant of thyroid papillary carcinoma: a clinicopathologic study of six cases, Pure versus follicular variant of papillary thyroid carcinoma: clinical features, prognostic factors, treatment, and survival, Pure versus follicular variant of papillary thyroid carcinoma: clinical features, prognostic factors, Hurthle cell carcinoma: a critical histopathologic appraisal, Guest editorial: two proposals regarding the terminology of thyroid tumors, BRAF mutations are associated with some histological types of papillary thyroid carcinoma, PAX8-PPARgamma rearrangement in thyroid tumors: RT-PCR and immunohistochemical analyses, Histologic growth patterns (“subvariants”), More than lobectomy but less than total thyroidectomy. Tall-cell carcinoma: Tall-cell carcinoma is a more aggressive form of thyroid carcinoma that differs from the usual form by showing tall columnar cells. Endocr Pathol. All 43 patients who had noninvasive, encapsulated FVPTC lacked evidence of lymph node metastases. Conclusions: Irregular clusters of nonendothelialized tumor cells that were not attached to the vessel wall represented artefactual dislodgement of tumor during sectioning and did not qualify as vascular invasion. The follicular variant of papillary carcinoma is a controversial entity. The numbers of foci of vascular invasion in tumor capsule (intracapsular vascular invasion) and outside the tumor capsule (extracapsular vascular invasion) were recorded. At age 58, a 3.4 cm tumor, papillary carcinoma, follicular variant, well differentiated diagnosed 11/28/11. Infiltrative follicular variant papillary carcinoma without a complete tumor capsule. This sample of the infiltrative variant of papillary thyroid carcinoma (FVPTC), which measured 2.3 cm, was from a male patient age 53 years who presented with metastatic carcinoma in 13 of 19 cervical lymph nodes. FVPTC appeared to be a heterogeneous disease composed of 2 distinct groups: an infiltrative/diffuse (nonencapsulated) subvariant, which resembles classic papillary carcinoma in its metastatic lymph node pattern and invasive growth, and an encapsulated form, which behaves more like FTA/FTC. T he follicular variant of papillary thyroid carcinoma (FVPTC) is a common variant comprising 15–20% of all papillary thyroid carcinoma (PTC) (1,2).The diagnosis of FVPTC is based on its histologic features comprising characteristic nuclear features of PTC and an exclusive or predominant (>50%) follicular growth pattern without well-formed papillae (3,4). JRC:18913: Papillary carcinoma of the thyroid (classic type). Papillary thyroid cancer (as is the case with follicular thyroid cancer) typically occurs in the middle-aged, with a peak incidence in the 3 rd and 4 th decades. 2021 Jan 4. doi: 10.1007/s12022-020-09650-1. Results of molecular analysis of cases initially submitted to Group 1. eTable 3. No tumor capsular invasion. Encapsulated FVPTCs have been reported to have virtually no recurrence risk or metastatic potential and to harbor RAS mutations but not BRAF mutations. Follicular variant of papillary thyroid carcinoma represents 30% of all papillary thyroid cancers and, like the classic type of papillary cancer, has a good prognosis overall. BACKGROUND. Tall cell variant Full size image. No perineural invasion seen. Encapsulated malignant follicular cell-derived thyroid tumors. What if many follicular variant papillary thyroid carcinomas are not malignant? Follicular variant, encapsulated without invasion is now termed Noninvasive follicular thyroid neoplasm with papillary -like nuclear-features (NIFTP) given its low malignant potential. Fifty-nine of 78 patients (76%) were female. Careers. Accessibility only), all tumors that were included after the initial review were reexamined microscopically by four board-certified pathologists with special interest in thyroid neoplasia, (R.A.G., G.T., D.L.C., N.K.) (B) Medium-power view showing dense, pink-staining colloid that often is seen in FVPTC (arrow). Liu J, Singh B, Tallini G, Carlson DL, Katabi N, Shaha A, Tuttle RM, Ghossein RA. Fifty-four patients underwent a lobectomy, and 21 patients underwent total thyroidectomy. Epub 2020 Mar 2. In all statistical analysis, a 2-tailed P value < .05 was considered statistically significant. Unable to load your collection due to an error, Unable to load your delegates due to an error. Google Scholar; 3 Lin HW, Bhattacharyya N 2010 Clinical behavior of follicular variant of papillary thyroid carcinoma presentation and survival. However, there are no outcome data with long median follow-up from a large number of patients with FVPTC. A median of 12 slides per patient were reviewed. Terminology. 2010 Dec;21(4):212-8. doi: 10.1007/s12022-010-9141-8. Recent reports indicate that encapsulated FVPTC behaves like follicular adenomas, while infiltrative FVPTC behaves like cPTC. FOIA The gender distribution, age at presentation, and tumor size did not differ between patients with encapsulated and nonencapsulated FVPTC. Report. What if many follicular variant papillary thyroid carcinomas are not malignant? Bethesda, MD 20894, Copyright Encapsulated FVPTCs have been reported to have virtually no recurrence risk or metastatic potential and to … Vascular invasion was defined as invasion of a vessel located within or outside the tumor capsule. The clinical, histologic, and molecular data gathered to date strongly suggest that FVPTC is a heterogeneous disease composed of 2 distinct group of tumors: a nonencapsulated (infiltrative and diffuse) subvariant, which resembles classic PTC in its invasive growth and metastatic lymph node pattern, and encapsulated FVPTC. Indeed, encapsulated FVPTC seem to have a behavior much closer to that of follicular tumors (i.e., FTA and FTC) rather than classic PTC.

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