BP was defined as suppressed thyroglobulin (Tg) levels <1 ng/ml and rhTSH-stimulated thyroglobulin (St-Tg) >1ng/ml, with no evidence of structural disease. Following a diagnosis of papillary thyroid cancer (PTC) by fine needle aspiration biopsy, the patient underwent total thyroidectomy and right lateral neck lymph node dissection. To evaluate the outcome of differentiated thyroid cancer (DTC) patients with biochemical persistence of disease (BP) after initial treatment (total thyroidectomy with or without lymph node dissection (LND) and thyroid remnant ablation). The last 10 years has seen a renewed interest in a risk adapted management approach to differentiated thyroid cancer. Aim: The aim of the study is to evaluate the value of thyroid-stimulating hormone (TSH)-stimulated thyroglobulin (sTg) measurements by the end of the 1 st-year postablation in differentiated thyroid cancer (DTC) patients with biochemical non complete response (indeterminate and incomplete response). Objective: In a cohort of medullary thyroid cancer (MTC) patients with biochemical incomplete responses, 37 to 48% developed structural persistent disease; however, few indictors were available to distinguish those patients who were more likely to develop structural disease. All 48 patients with a structural incomplete response to therapy died of thyroid cancer, so the disease-specific mortality was 15% in the entire cohort. The univariate and multivariate analyses were further conducted to identify factors associated with incomplete response (IR, including BIR and SIR). ... Data on the incidence and evolution of thyroid cancer in acromegaly are controversial. The response to treatment was categorized as excellent, indeterminate, biochemical incomplete, and structural incomplete as per guidelines of the American Thyroid Association. We evaluated 102 patients with PTC showing a BIR during the first 12–24 months after total thyroidectomy and radioactive iodine therapy. RFU was: 83% (19/23) patients with no evidence of disease, 9% (2/23) with indeterminate response, 4% (1/23) with biochemical incomplete response and 4% (1/23) with structural incomplete response, at a median time of FU of 36.5 months. … Academic Article Overview abstract . , 77 ( 1 ) ( 2012 ) , pp. Endocrine , Aug 2014 R. Michael Tuttle To assess the value of 18F-FDG-PET/CT for detecting recurrent/persistent disease in patients with biochemical incomplete (BIR) or indeterminate respon… Spontaneous remission in thyroid cancer patients after biochemical incomplete response to initial therapy Clin Endocrinol (Oxf). We hypothesized that the relationship between preoperative calcitonin (Ctn) and postoperative Ctn (within … In: Endocrine . Purpose The aim of this study was to evaluate the long-term clinical outcomes of papillary thyroid carcinoma (PTC) patients exhibiting biochemical incomplete response (BIR) to initial therapy. OBJECTIVE: To validate the American Thyroid Association (ATA) initial risk of recurrence scheme and the Memorial Sloan Kettering Cancer Center (MSKCC) response to therapy re-stratification approach in a large cohort of patients with … Response to therapy was recorded for the first time 6 to 18 months after the first therapy (ie, initial DRS); thereafter during and at end of follow-up. A 61-year-old asymptomatic female patient having no risk factors for thyroid carcinoma underwent neck ultrasound. ... and overall survival.Sixty-three patients (33%) had a biochemical incomplete response while 129 (67%) had a structural incomplete response. In other cases, the response was classified as either biochemical or structural incomplete response or indeterminate response as defined in American Thyroid Association guidelines 2009 . R. Michael Tuttle Received: 24 December 2013 / Accepted: 13 February 2014 / Published online: 11 March 2014 Springer Science+Business Media … Biochemical and structural (predominantly thyroid bed, lung and bone) incomplete response was observed in 6 and 63 patients, respectively. At the final follow-up, 88, 4 and 0 % of patients in excellent, biochemical incomplete, and structural incomplete response groups attained NED, respectively. Aim: Based on the response criteria of the 2015 American Thyroid Associations guidelines, our objectives were to -determine the response rate when using a low dose of -131-I GBq in patients with low-risk differentiated thyroid cancer (LRDTC) and the influence of clinical and analytical variables on the prediction of complete response. Dynamic risk stratification for medullary thyroid cancer according to the response to initial therapy. The response to treatment was categorized as excellent, indeterminate, biochemical incomplete, and structural incomplete as per guidelines of the American Thyroid Association. Differentiated thyroid cancer (DTC) is generally characterized by good prognosis and low disease-specific mortality.1, 2 The therapeutic approach and follow-up of patients with DTC is currently individualized according to the risk of recurrence (RR). At the time of final follow‐up, 34% of the biochemical incomplete response patients had been re‐classified as having no evidence of disease (NED) without having received any additional therapy beyond continue levothyroxine suppression. In differentiated thyroid cancer, an incomplete structural response to therapy is associated with significantly worse clinical outcomes than only an incomplete thyroglobulin response. Persistent disease was defined as either structural or biochemical incomplete response. Response to RAI therapy was evaluated as excellent, indeterminate, biochemical incomplete or structural incomplete response (ER, IDR, BIR or SIR) with a median follow-up of 780 days. RESULTS: Of the 225 patients, 69 (31%) had incomplete response. Role of 18 F-FDG-PET/CT in patients with differentiated thyroid cancer with biochemical incomplete or indeterminate response to treatment Utilidad de la tomografía por emisión de positrones con 18 F-FDG (18 F-FDG PET/TC) en pacientes con carcinoma diferenciado de tiroides con respuesta bioquímica incompleta o indeterminada / Papillary thyroid carcinomas with biochemical incomplete or indeterminate responses to initial treatment : repeat stimulated thyroglobulin assay to identify disease-free patients. Response to initial therapy of differentiated thyroid cancer predicts the long-term outcome better than classical risk stratification systems. ... At the final follow-up, 88, 4 and 0 % of patients in excellent, biochemical incomplete, and structural incomplete response groups attained NED, respectively. Incomplete response was documented in 8, 54 and 92% of low-, intermediate- and high-risk patients based on ATA recommendation. Introduction. The aim of this study was to evaluate the long-term clinical outcomes of papillary thyroid carcinoma (PTC) patients exhibiting biochemical incomplete response (BIR) to initial therapy. Therefore, in 2011, Vaisman et al. Spontaneous remission in thyroid cancer patients after biochemical incomplete response to initial therapy. At the time of final follow-up, 34% of the biochemical incomplete response patients had been re-classified as having no evidence of disease (NED) without having received any additional therapy beyond continue levothyroxine suppression. 132 - 138 CrossRef View Record in Scopus Google Scholar Patients and methods: One hundred patients with DTC underwent near-total … Endocrine (2014) 46:363–364 DOI 10.1007/s12020-014-0213-2 EDITORIAL Optimal management of a biochemical incomplete response to therapy in differentiated thyroid cancer: aggressive treatment or cautious observation? We now view risk stratification as an ongoing, dynamic process that begins with initial estimates of the risk of death from thyroid cancer and risk of recurrent/ persistent disease for each patient [1]. 4%. Two patients with a structural incomplete response to therapy had widely metastatic, poorly differentiated thyroid carcinoma and died within 3 months of their thyroid surgery. Optimal management of a biochemical incomplete response to therapy in differentiated thyroid cancer: aggressive treatment or cautious observation? 4%. Differentiated thyroid cancer (DTC) is the most common endocrine malignancy , and ... course of the disease over a relatively long period of follow-up and attempted to identify predictive factors of incomplete biochemical or structural response in these groups of …

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